基因芯片技术在病原细菌检测中的应用

基因芯片技术具有快速、高通量、平行化等优点，在病原细菌检测中有广泛的应用前景，选择细菌适宜的靶基因是芯片制备的关键之一。用细菌核糖体基因做靶基因的芯片技术，虽然应用广泛，但仍存在一些不足，随着基因组信息及基因功能的深入研究，包括毒力基因、耐药基因等具有较好种属特异性的细菌基因不断被发现，为芯片技术检测病原细菌提供了更多特异的靶基因，使检测结果更加灵敏、准确，在病原细菌研究中将发挥更大的作用。

The Application of Gene Microarray in Detecting Pathogenic Bacteria

DNA microarray bears the advantages of fast,high-throughput,parallel-oriented,and has a broad application prospect in the detection of bacterial pathogens.One of the key step is how to select the appropriate target gene of bacteria.The bacterial ribosomal gene has been utilized as universal target gene;however,it has the shortage of non-specific hybridization.With more and more genome information and gene functions available,many more genes reveal better genus or species-specificity,such as virulence genes ...