Novel three-component synthesis and antiproliferative properties of diversely functionalized pyrrolines |
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| Authors: | Magedov Igor V Luchetti Giovanni Evdokimov Nikolai M Manpadi Madhuri Steelant Wim F A Van Slambrouck Severine Tongwa Paul Antipin Mikhail Yu Kornienko Alexander |
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| Institution: | Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA. |
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| Abstract: | Diversely substituted 2-pyrrolines have been prepared by a novel multicomponent process involving a reaction of various N-(aryl- and alkylsulfonamido)-acetophenones with aldehydes and malononitrile. While the reaction is highly regioselective, it is not stereoselective, generating a mixture of cis and trans 2-pyrrolines. A number of analogs from both cis and trans 2-pyrroline libraries were found to have antiproliferative activity in human cancer cell lines. |
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