RecO is essential for DNA damage repair in Deinococcus radiodurans |
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| Authors: | Xu Guangzhi Wang Liangyan Chen Huan Lu Huiming Ying Nanjiao Tian Bing Hua Yuejin |
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| Affiliation: | Key Laboratory of Chinese Ministry of Agriculture and Zhejiang Province for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou 310029, China. |
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| Abstract: | Here we present direct evidence for the vital role of RecO in Deinococcus radiodurans's radioresistance. A recO null mutant was constructed using a deletion replacement method. The mutant exhibited a growth defect and extreme sensitivity to irradiation with gamma rays and UV light. These results suggest that DNA repair in this organism occurs mainly via the RecF pathway. |
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