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Lysianadioic acid, a carboxypeptidase B inhibitor from Lysiana subfalcata |
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| Authors: | Buchanan Malcolm S Carroll Anthony R Edser Annette Sykes Melissa Fechner Gregory A Forster Paul I Guymer Gordon P Quinn Ronald J |
| Affiliation: | Eskitis Institute, Griffith University, Brisbane, Qld 4111, Australia. |
| Abstract: | A new natural product, lysianadioic acid, was isolated from the plant Lysiana subfalcata as a carboxypeptidase B (CPB) inhibitor. It is a potent inhibitor of CPB with an IC(50) of 0.36 microM. This is the first known example of a small molecule CPB inhibitor isolated from plant origin. Its structure was determined by NMR spectroscopy. |
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