Dehydroepiandrosterone and melatonin prevent Bacillus anthracis lethal toxin-induced TNF production in macrophages |
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Authors: | S Shin G-H Hur Y-B Kim G-B Yeon K-J Park Y-M Park W-S Lee |
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Institution: | (1) CBR Department, Agency for Defense Development, Taejon, Korea;(2) Department of Biological Science, Sung Kyun Kwan University, Suwon, Korea |
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Abstract: | The lethal toxin of Bacillus anthracis, which is composed of two separate proteinaceous exotoxins, namely protective antigen and lethal factor, is central to the
pathogenesis of anthrax. Low levels of this toxin are known to induce release of cytokines such as tumor necrosis factor α
(TNF-α). In the present study we investigated the effect of dehydroepiandrosterone (DHEA), melatonin (MLT), or DHEA + MLT
on production of lethal toxin-induced TNF-α in mouse peritoneal macrophages. We found that treatment with DHEA significantly
inhibited the TNF-α production caused by anthrax lethal toxin. Exposure of MLT to anthrax lethal toxin-treated macrophages
also decreased the release of TNF-α to the extracellular medium as compared to the control. However, combined use of DHEA
and MLT also inhibited TNF-α release, but not more than single therapies. These results suggest that DHEA and MLT may have
a therapeutic role in reducing the increased cytokine production induced by anthrax lethal toxin.
This revised version was published online in July 2006 with corrections to the Cover Date. |
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Keywords: | anthrax lethal toxin cytokine dehydroepiandrosterone melatonin tumor necrosis factor α |
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