| Abstract: | The work presents the results of the comparative study of the luminol-dependent chemiluminescence of human neutrophils stimulated with peptidoglycans of 14 staphylococcal species. The intensity of chemiluminescence greatly varied, which was not linked with specific antigenic and structural features of peptidoglycans. The maximal chemiluminescence was induced by S. aureus and S. cohnii peptidoglycans and the minimal chemiluminescence, by S. lentus and S. epidermidis peptidoglycans. The data obtained in experiments on cross restimulation with homologous and heterologous peptidoglycans suggest that the mechanisms of neutrophil activation are similar in character, differing from the mechanism of latex-induced chemiluminescence. These data were analyzed from the viewpoint of the heterogeneity of bacterial peptidoglycans and its effect on their relationship with neutrophils. |
