Immune recognition of proteins: Conclusions,dilemmas and enigmas |
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Authors: | John A. Smith George D. Rose |
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Abstract: | The immune system distinguishes between two types of antigenic sites: one of these binds to immunoglobulins (IgGs) (i.e. antibodies), while the other binds to receptor molecules on T lymphocytes (i.e. the T-cell receptors (TcRs)). The latter interaction occurs only when the antigen is presented in association with a self-transplantation antigen, a so-called MHC-restriction element. This article discusses what is known about the structure of antigenic sites and their molecular interactions with antibodies, MHC-restriction elements, and T-lymphocyte receptors. |
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