Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum |
| |
Authors: | Atsushi Kato Megumi Yasui Natsuki Yano Yasuyoshi Kawata Kuniaki Moriki Isao Adachi Jackie Hollinshead Robert J Nash |
| |
Institution: | 1. Department of Hospital Pharmacy, University of Toyama, Toyama 930-0194, Japan;2. Institute of Grassland and Environmental Research, Plas Gogerddan, Aberystwyth, Ceredigion SY23 3EB, United Kingdom |
| |
Abstract: | Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus 30a with an IC50 value of 969 μM but its N-oxide showed no inhibition of this enzyme. Sinomenine inhibited this enzyme in a noncompetitive manner with a Ki of 762 μM. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|