Bioactive chemical constituents of Caesalpinia bonduc (Fabaceae) |
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| Authors: | Athar Ata Elikana M Gale Radhika Samarasekera |
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| Institution: | 1. Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, MB, Canada, R3B 2E9;2. Natural Products Development Group, Industrial Technology Institute, Colombo, Sri Lanka |
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| Abstract: | Phytochemical studies on the ethanolic extracts of Caesalpinia bonduc (Fabaceae) yielded two new homoisoflavonoids, caesalpinianone, and 6-O-methylcaesalpinianone along with five known natural products, namely, hematoxylol, stereochenol A, 6′-O-acetylloganic acid, 4′-O-acetylloganic acid, and 2-O-β-d-glucosyloxy-4-methoxybenzenepropanoic acid. Structures of these compounds were elucidated with the aid of extensive NMR spectral studies. All of these compounds exhibited different levels of glutathione S-transferase (GST) inhibitory and antifungal activities. |
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