Hospital-based prevalence and sensitivity of high-risk human papillomavirus in Thai urban population |
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| Authors: | Komsun Suwannarurk Pairath Tapanadechopol Junya Pattaraarchachai Sutatip Bhamarapravati |
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| Institution: | 1. Molecular Oncology Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil;2. Center for the Researcher Support, Barretos Cancer Hospital, Barretos, São Paulo, Brazil;3. Cancer Prevention Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil;4. Pathology Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil;5. Santa Casa de São Paulo Medical School, FCMSCSP, São Paulo, Brazil;6. Faculty of Medicine, Department of Radiology and Basic Oncology, São Paulo University, FMUSP, São Paulo, Brazil;7. Laboratory of Medical Investigation (LIM)14, Faculty of Medicine, São Paulo University, FMUSP, São Paulo, Brazil;8. Life and Health Sciences Research Institute, ICVS, School of Health Sciences, Minho University, Braga, Portugal;9. ICVS/3B''s–PT Government Associate Laboratory, Braga/Guimarães, Portugal;1. Department of Laboratory Medicine, Seoul National University Hospital, Seoul, South Korea;2. Department of Laboratory Medicine, Konkuk University Medical Center, Seoul, South Korea |
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| Abstract: | Background: To study the prevalence of high-risk human papillomavirus (HPV) types 16, 18, 31 and 33 in healthy Thai women using polymerase chain reaction (PCR) technique. Material and method: Two hundred and sixty three healthy urban women in Pathumthani, Thailand were recruited. Cervical cancer screening was performed and residual specimen from Pap smears was subjected to PCR to identify the presence of HPV types 16, 18, 31 and 33. Individuals’ demographic, health-specific and sexual behavior data were also collected. Results: Colposcopic biopsy revealed cases with high-grade squamous intraepithelial lesions (HSIL) and low-grade squamous intraepithelial lesions (LSIL). HPV 16 and 18 positive results were associated with abnormal Pap smears. Genotyping gave a 6.1%, 11.8%, 12.1%, and 14.1%, prevalence for HPV types 16, 18, 31 and 33, while 25% were infected with multiple HPV types. Discussion: High-risk HPV screening, used with abnormal pathology of HSIL gives 100% sensitivity and negative predictive value. Data from patient showed not significant correlation with neither different religion level of education, marital status, age of first sexual experience nor the number of sexual partners. Thus high-risk HPV screening is a recommended procedure with excellent sensitivity for detecting HSIL. |
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