Baseline alcohol consumption,type of alcoholic beverage and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition-Norfolk study |
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| Authors: | Jin Young Park Panagiota N Mitrou Christina C Dahm Robert N Luben Nicholas J Wareham Kay-Tee Khaw Sheila A Rodwell |
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| Institution: | 1. Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom;2. Medical Research Council Centre for Nutritional Epidemiology in Cancer Prevention and Survival, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom;3. Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke''s Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom;1. Institute of Digestive Disease, Chinese University of Hong Kong, 7/F, Lui Che Woo Clinical Science Building, Prince of Wales Hospital, Shatin, NT, Hong Kong Special Administrative Region;2. School of Public Health and Primary Care, Chinese University of Hong Kong, 4/F, School of Public Health and Primary Care, Prince of Wales Hospital, Shatin, NT, Hong Kong Special Administrative Region;1. Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia;2. Department of Surgery and Gastroenterology, Queen Elizabeth II Jubilee Hospital, Brisbane, Queensland, Australia;3. Department of Colon and Rectal Surgery, Royal Brisbane and Women''s Hospital, Brisbane, Queensland, Australia;1. Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts;3. Division of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts;4. Department of Medicine, Brigham and Women''s Hospital and Harvard Medical School, Boston, Massachusetts;6. Division of Gastroenterology, Brigham and Women''s Hospital and Harvard Medical School, Boston, Massachusetts;7. Department of Health Care Policy, Brigham and Women''s Hospital and Harvard Medical School, Boston, Massachusetts;5. Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;12. Harvard Vanguard Medical Associates, Harvard Medical School, Boston, Massachusetts;8. Center for Patient Safety, Harvard Medical School, Boston, Massachusetts;9. Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts;10. Center for Evaluation, Harvard Medical School, Boston, Massachusetts;1. Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, China;2. Institute of Environmental Health, Zhejiang University School of Medicine, Hangzhou, China |
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| Abstract: | Excessive alcohol consumption has been associated with increased risk of colorectal cancer (CRC). However, the effect of modest alcohol consumption or of particular types of beverages on CRC risk remains unclear. We examined whether consumption of total alcohol or specific types of alcoholic beverages relate to overall or site-specific CRC risk in a prospective population study of 24,244 participants and 407 incident CRC cases after 11 years of follow-up. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. Consumption of specific alcoholic beverages at baseline was collected using a detailed health and lifestyle questionnaire. Total alcohol consumption was not associated with CRC risk before or after adjustment for age, sex, weight, height, and smoking status (HR: 0.80, 95% CI: 0.51–1.26 for alcohol consumption of ≥21 units/week compared with non-drinkers), and further adjustment for education level, exercise, family history of CRC, and dietary factors did not significantly alter the risk estimates (HR: 0.70, 95% CI: 0.44–1.13). No significant associations were observed between consumption of specific alcoholic beverages (beer, sherry, or spirits) and CRC risk when compared with non-drinkers after adjustment for lifestyle and dietary factors. Daily consumption of ≥1 unit of wine appeared inversely related to CRC risk (HR: 0.61, 95% CI: 0.40–0.94). No evidence was found for sex-specific relationships, and further exclusion of cases incident within 3 years of baseline did not change the associations observed. In this population-based UK cohort, we did not find any significant adverse effect of alcohol over the moderate range of intake on colorectal cancer risk. |
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