Dihydronaphthalenones from the endophytic fungus Botryosphaeria sp. BCC 8200 |
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| Authors: | Masahiko Isaka Arunrat Yangchum Pranee Rachtawee Punsa Khoyaiklang Nattawut Boonyuen Saisamorn Lumyong |
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| Institution: | 1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;2. Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand |
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| Abstract: | Five new dihydronaphthalenones (1, 2a/2b, 3a/3b), four of which were isolated as two inseparable mixtures of isomers, together with two known compounds, 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (4) and siderin (5), were identified as secondary metabolites of the endophytic fungus Botryosphaeria sp. BCC 8200. The structures were elucidated by interpretation of NMR spectroscopic and mass spectrometry data. Compounds 2a/2b, 3a/3b, and 5 exhibited weak cytotoxic activities against cancer cell lines. |
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