Job strain and risk of esophageal and cardia cancers |
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| Authors: | Catarina Jansson Kerstin Jeding Jesper Lagergren |
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| Institution: | 1. Department of General Surgery, Laiwu People''s Hospital, Laiwu 271100, Shandong, China;2. Shandong University, Jinan 250100, Shandong, China;3. Second Department of Health, Laiwu People''s Hospital, Laiwu 271100, Shandong, China;4. Department of Gastrointestinal Surgery, Jining No. 1 People''s Hospital, Jining 272011, Shandong, China;1. Department of Urology, Chaim Sheba Medical Center, Tel Hashomer, Israel;2. Abarbanel Mental Health Center, Bat-Yam, Israel;3. Sackler School of Medicine, Tel-Aviv University, Israel |
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| Abstract: | BackgroundFew studies have investigated work-related stress in relation to esophageal or cardia cancers.MethodsOur nationwide Swedish population-based case-control study included 189 and 262 esophageal and cardia adenocarcinoma cases respectively, 167 esophageal squamous-cell carcinoma cases and 820 controls. We derived each study participant's occupation of longest duration from occupational histories and applied a psychosocial job-exposure matrix. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using conditional logistic regression, in multivariable models.ResultsJob strain was positively associated with risk of esophageal adenocarcinoma (OR 3.2, 95% CI 1.0–9.8) and squamous-cell carcinoma (OR 4.0, 95% CI 1.6–10.5), but not with cardia adenocarcinoma. No associations regarding demands, control, social support or iso strain were observed, except for a positive association between high control and risk of esophageal squamous-cell carcinoma (OR 1.5, 95% CI 1.0–2.3).ConclusionJob strain seems to increase the risk of both histological types of esophageal cancer. |
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