Amino acid recognition and gene regulation by riboswitches |
| |
| Authors: | Alexander Serganov Dinshaw J Patel |
| |
| Institution: | 1. Biophysics Program, Stanford University, Stanford, CA 94305, USA;2. Department of Physics, Stanford University, Stanford, CA 94305, USA;3. Department of Applied Physics, Stanford University, Stanford, CA 94305, USA;4. Department of Biology, Stanford University, Stanford, CA 94305, USA;1. Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA;2. Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA;3. A.A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127994, Russia;1. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran;2. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;3. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran;4. Research Institute for Fundamental Sciences (RIFS), University of Tabriz, Tabriz, Iran;5. The School of Advanced Biomedical Sciences (SABS), Tabriz University of Medical Sciences, Tabriz, Iran |
| |
| Abstract: | Riboswitches specifically control expression of genes predominantly involved in biosynthesis, catabolism and transport of various cellular metabolites in organisms from all three kingdoms of life. Among many classes of identified riboswitches, two riboswitches respond to amino acids lysine and glycine to date. Though these riboswitches recognize small compounds, they both belong to the largest riboswitches and have unique structural and functional characteristics. In this review, we attempt to characterize molecular recognition principles employed by amino acid-responsive riboswitches to selectively bind their cognate ligands and to effectively perform a gene regulation function. We summarize up-to-date biochemical and genetic data available for the lysine and glycine riboswitches and correlate these results with recent high-resolution structural information obtained for the lysine riboswitch. We also discuss the contribution of lysine riboswitches to antibiotic resistance and outline potential applications of riboswitches in biotechnology and medicine. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
