Synthesis of bioinorganic antimicrobial peptide nanoparticles with potential therapeutic properties |
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Authors: | Eby D Matthew Farrington Karen E Johnson Glenn R |
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Institution: | Universal Technology Corporation, Applied Research Associates, Inc., Florida, USA. matt.eby.ctr@tyndall.af.mil |
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Abstract: | Amphiphilicity and cationicity are properties shared between antimicrobial peptides and proteins that catalyze biomineralization reactions. Merging these two functionalities, we demonstrate a reaction where a cationic antimicrobial peptide catalyzes self-biomineralization within inorganic matrices. The resultant antimicrobial peptide nanoparticles retain biocidal activity, protect the peptide from proteolytic degradation, and facilitate a continuous release of the antibiotic over time. Taken together, these properties demonstrate the therapeutic potential of self-synthesizing biomaterials that retain the biocidal properties of antimicrobial peptides. |
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