Mechanisms of oral tolerance revisited |
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Authors: | Jun Wang Rene EM Toes |
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Institution: | 1. Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2300, RC, Leiden, The Netherlands
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Abstract: | Oral tolerance induction is thought to depend on special antigen presenting cells in the gut. A new report in the previous issue of Arthritis Research & Therapy supports this idea by demonstrating that indoleamine 2,3-dioxygenase-expressing dendritic cells in Peyer's patches from orally tolerized mice suppress T-cell responses via the generation of CD4+CD25+ regulatory T cells. This finding provides novel input into the mechanisms of oral tolerance that could further facilitate its use for the treatment of autoimmunity and chronic inflammatory reactions. |
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