Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase |
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| Authors: | Ding Yili Smith Kenneth L Varaprasad Chamakura V N S Chang Eugene Alexander John Yao Nanhua |
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| Institution: | Drug Discovery, Valeant Pharmaceuticals Research & Development, 3300 Hyland Avenue Costa Mesa, CA 92626, USA. yi_ding93@yahoo.com |
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| Abstract: | Several thiazolone-based sulfonamides were prepared, utilizing various hetero-aryl sulfonyl chlorides and different aldehydes, as inhibitors of NS5B polymerase, to target HCV. The best compound showed 0.6 microM corrected] of IC50 inhibitory activity. |
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