| 真菌苯二酚内酯聚酮类化合物生物合成研究进展 |
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| 引用本文： | 王晓婧,陆伟,徐玉泉,梁晓东. 真菌苯二酚内酯聚酮类化合物生物合成研究进展[J]. 生物技术进展, 2015, 5(2): 89-94. DOI: 10.3969/j.issn.2095-2341.2015.02.03 |
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| 作者姓名： | 王晓婧 陆伟 徐玉泉 梁晓东 |
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| 作者单位： | 1.中国农业科学院生物技术研究所, 北京 1000812.国药一心制药有限公司, 北京 100176 |
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| 基金项目： | 国家863计划项目(2012AA02A703);农业部引进国际先进农业科学技术计划项目（2015-Z1）资助。 |
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| 摘 要： | 真菌苯二酚内酯类聚酮化合物具有抗癌和调节免疫系统等重要的生物活性，其生物合成是近年来的研究热点。介绍了苯二酚内酯的双聚酮合酶协作合成机制和组合生物合成，并以几种真菌苯二酚内酯生物合成途径为例，综述了相关的研究进展，以期为研究者提供参考。
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| 关 键 词： | 苯二酚内酯 真菌聚酮 聚酮合酶 生物合成 组合生物合成 |
| 收稿时间： | 2015-01-22 |
Progress on the Biosynthesis of Fungal Benzenediol Lactone Polyketides |
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| WANG Xiao-jing,LU Wei,XU Yu-quan,LIANG Xiao-dong. Progress on the Biosynthesis of Fungal Benzenediol Lactone Polyketides[J]. CURRENT BIOTECHNOLOGY, 2015, 5(2): 89-94. DOI: 10.3969/j.issn.2095-2341.2015.02.03 |
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| Authors: | WANG Xiao-jing LU Wei XU Yu-quan LIANG Xiao-dong |
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| Affiliation: | 1.Biotechnology Research Institute, Chinese Academy of Agricultural Science, Beijing 100081, China;2.Sinopharm A-THINK Pharmaceutical Co., Ltd., Beijing 100176, China |
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| Abstract: | Fungal benzenediol lactones, biosynthesized by polyketide synthases, are important pharmacophores with wide-ranging bioactivities including anti-cancer and immune system modulatory effects. Its biosynthesis has become research focus in recent years. A comprehensive review was made about collaborative biosynthetic mechanism of two type I iterative polyketide synthases, and combinatorial biosynthesis of benzenediol lactones. As examples, the biosynthesis pathways of a few fungal benzenediol lactones were highlighted, which was expected provide reference for related research. |
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| Keywords: | benzenediol lactone fungal polyketides polyketide synthase biosynthesis combinatorial biosynthesis |
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