| 非经典的蛋白质分泌途径 |
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| 引用本文： | 刘刚,王清明,陈惠鹏.非经典的蛋白质分泌途径[J].生物技术通讯,2005,16(1):53-55. |
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| 作者姓名： | 刘刚 王清明 陈惠鹏 |
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| 作者单位： | 1. 军事医学科学院,放射医学研究所,北京,100850
2. 军事医学科学院,生物工程研究所,北京,100071 |
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| 基金项目： | 国家自然科学基金项目(30170205) |
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| 摘 要： | 蛋白质分泌是细胞间进行信息传递的重要方式之一。一般的分泌蛋白在其N端都具有信号肽序列，可以通过经典的内质网-高尔基体途径进行运输，并最终分泌到细胞外。近来发现细胞内存在另一类分泌蛋白，它们能够分泌到细胞外发挥功能，但却没有典型的信号肽序列，被称为非经典分泌蛋白。越来越多的证据表明，这类蛋白质的分泌有其独特的机制。本综述了这类蛋白质的各种分泌机制及可能的生理意义。
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| 关 键 词： | 非经典分泌蛋白质 信号肽 分泌机制 生理学意义 细胞间信息传递 |
| 文章编号： | 1009-0002(2005)01-0053-03 |
| 修稿时间： | 2004年6月2日 |
Non-classical Secretory Pathway |
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| LIU Ganga,WANG Qing-minga,CHEN Hui-pengba.Non-classical Secretory Pathway[J].Letters in Biotechnology,2005,16(1):53-55. |
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| Authors: | LIU Ganga WANG Qing-minga CHEN Hui-pengba |
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| Institution: | LIU Ganga,WANG Qing-minga,CHEN Hui-pengba. Institute of Radiation Medicine,Beijing 100850, b. Institute of Biotechnology,Beijing 100071,Academy of Military Medical Sciences,China |
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| Abstract: | Secretory proteins play important roles in intercellular communication. The classical secretory protein, which contains a typical signal peptide, is transported through ER-Golgi route. Recently many proteins with a defined extracellular function but lacking signal peptide have been identified and are called non-classical secretory proteins. Increasing evidence shows that the specific mechanisms must be existed for the secretion of the non-classical secretory protein. In this paper, the various secretory mechanisms of the non-classical secretory proteins and the hypotheses on the necessity or advantages of the non-classical secretion were discussed. |
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| Keywords: | secretion signal peptide non-classical secretory pathway |
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