The "Goldilocks Effect" in Cystic Fibrosis: identification of a lung phenotype in the <Emphasis Type="Italic">cftr</Emphasis> knockout and heterozygous mouse期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

The "Goldilocks Effect" in Cystic Fibrosis: identification of a lung phenotype in the cftr knockout and heterozygous mouse

Authors:	J?Craig Cohen author-information" > author-information__contact u-icon-before" > mailto:ccohen@lsuhsc.edu" title=" ccohen@lsuhsc.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Lennart?KA?Lundblad,Jason?HT?Bates,Michael?Levitzky,Janet?E?Larson

Affiliation:	1.Departments of Medicine and Physiology,Louisiana State University, School of Medicine,New Orleans,USA;2.Vermont Lung Center,The University of Vermont,Burlington,USA;3.Ochsner Children's Research Institute,Ochsner Clinic Foundation,New Orleans,USA;4.Department of Clinical Physiology,Malm? University Hospital, Lund University,Malm?,Sweden

Abstract:	Background Cystic Fibrosis is a pleiotropic disease in humans with primary morbidity and mortality associated with a lung disease phenotype. However, knockout in the mouse of cftr, the gene whose mutant alleles are responsible for cystic fibrosis, has previously failed to produce a readily, quantifiable lung phenotype.

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