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A steady state analysis indicates that negative feedback regulation of PTP1B by Akt elicits bistability in insulin-stimulated GLUT4 translocation |
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| Authors: | Lopamudra?Giri,Vivek?K?Mutalik,KV?Venkatesh author-information" > author-information__contact u-icon-before" > mailto:venks@che.iitb.ac.in" title=" venks@che.iitb.ac.in" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
| Affiliation: | (1) Department of Chemical Engineering and School of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India |
| Abstract: | BackgroundThe phenomenon of switch-like response to graded input signal is the theme involved in various signaling pathways in living systems. Positive feedback loops or double negative feedback loops embedded with nonlinearity exhibit these switch-like bistable responses. Such feedback regulations exist in insulin signaling pathway as well. |
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