Inhibition of the benzo[a]pyrene-induced toxicity by allyl sulfides in human epidermal keratinocytes |
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Authors: | Hyang Sook Chun Hyun Jung Kim Yangha Kim Hyun Joo Chang |
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Affiliation: | (1) Korea Food Research Institute, Sungnam, 463-746, Korea;(2) Department of Food and Nutritional Science, Ewha Womans University, Seoul, 120-750, Korea |
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Abstract: | Diallyl sulfide (DAS) and diallyl disulfide (DADS) at 25 g ml–1decreased the benzo[a]pyrene (B[a]P)-induced colony growth inhibition of human epidermal keratinocytes. DAS and DADS decreased B[a]P-DNA and B[a]P-protein adducts by 65% and 49–55%, respectively. The B[a]P-induced ethoxyresorufin O-deethylase activity, a marker enzyme for cytochrome P450 1, was decreased from 3 to 1.7–1.9 nmol min–1 mg–1 microsomal protein by DAS and DADS treatments. The activity of glutathione S-transferase, a detoxifying enzyme for B[a]P, but was decreased by DADS, but was unaffected by DAS. |
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Keywords: | B[a]P-induced toxicity diallyl disulfide diallyl sulfide keratinocyte |
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