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Differentiation of noradrenergic and dopaminergic neurons in the cardiovascular system |
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| Authors: | M. Hadjiconstantinou J. C. Papademetriou N. H. Neff |
| Affiliation: | a Department of Pharmacology, The Ohio State University College of Medicine, Columbus, OH 43210, U.S.A. * Department of Pathology, University of Maryland Hospital, Baltimore, MD 21201, U.S.A. |
| Abstract: | Dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and norepinephrine (NE) are present in the rat cardiovascular system. All of the catechols can be partially depleted by administering 6-hydroxydopamine (6-HODA). When animals are pretreated with desipramine before 6-HODA, there is a selective partial depletion of DA and DOPAC. NE can be partially depleted with minimal effects on DA and DOPAC by administering N-(2-chloroethyl)N-ethyl-2-bromobenzylamine (DSP-4). These results are consistent with the hypothesis that independent dopaminergic and noradrenergic elements are present in the rat cardiovascular system and that DA is not solely a precursor for NE. NE, DA and DOPAC were assayed in human vessels and the pattern of distribution of the catechols is consistent with the results reported for animals. |
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