Heme biosynthesis in Methanosarcina barkeri via a pathway involving two methylation reactions |
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| Authors: | Buchenau Bärbel Kahnt Jörg Heinemann Ilka U Jahn Dieter Thauer Rudolf K |
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| Affiliation: | Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Strasse, D-35043 Marburg, Germany. |
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| Abstract: | The methanogenic archaeon Methanosarcina barkeri synthesizes protoheme via precorrin-2, which is formed from uroporphyrinogen III in two consecutive methylation reactions utilizing S-adenosyl-L-methionine. The existence of this pathway, previously exclusively found in the sulfate-reducing delta-proteobacterium Desulfovibrio vulgaris, was demonstrated for M. barkeri via the incorporation of two methyl groups from methionine into protoheme. |
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