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Baker’s yeast mediated preparation of (10-alkyl-10H-phenothiazin-3-yl)methanols |
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| Authors: | Monica To a Csaba Paizs Cornelia Majdik Paula Moldovan Lajos Novk Pl Kolonits va Szab Lszl Poppe Florin-Dan Irimie |
| Institution: | a Department of Biochemistry and Biochemical Engineering, Babes-Bolyai University, RO-3400 Cluj-Napoca, Arany János 11, Romania b Institute for Organic Chemistry and Research Group for Alkaloid Chemistry of the Hungarian Academy of Sciences, Budapest University of Technology and Economics, Gellért tér 4, H-1111, Budapest, Hungary c EGIS Pharmaceutical Work Ltd., P.O. Box 100, H-1474, Budapest 10, Hungary |
| Abstract: | A series of 10-alkyl-10H-phenothiazine-3-carbaldehydes (2a–h) were obtained by Vilsmeier–Haack formylation from the corresponding 10-alkyl-10H-phenothiazines (1a–h) and reduced to (10-alkyl-10H-phenothiazine-3-yl)methanols (3a–h) by two alternative methods. The baker’s yeast catalyzed reaction proved to be superior over the NaBH4 reduction and yielded the desired 3-hydroxymethylphenothiazines (3a–h) almost quantitatively. |
| Keywords: | N-alkylphenothiazines Formylation Aldehydes Reduction Baker’s yeast |
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