An attempt to treat patients who have injured spinal cords with intralesional implantation of concentrated autologous bone marrow cells |
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| Authors: | Ayhan Attar Murat Ayten Mevci Ozdemir Enver Ozgencil Melih Bozkurt Erkan Kaptanoglu Meral Beksac Yucel Kanpolat |
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| Affiliation: | Department of Neurosurgery, Ankara University, School of Medicine, Ankara, Turkey;Trabzon Public Hospital, Department of Neurosurgery, Trabzon, Turkey;Ergani Public Hospital, Department of Neurosurgery, Diyarbakir, Turkey;Department of Anesthesiology, Ankara University, School of Medicine, Ankara, Turkey;Department of Neurosurgery, Ankara Numune Hospital, Ankara, Turkey;Department of Hematology, Ankara University, School of Medicine, Ankara, Turkey;The Turkish Academy of Sciences, Ankara, Turkey;Max-Delbrück-Center for Molecular Medicine, Berlin-Buch, Germany;Stem Cell Lab, National Center for Cell Science, Ganeshkhind, Pune, India;Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, Tennessee, USA;Neuroscience Research Unit, Service of Surgical Research, Hospital Puerta de Hierro-Majadahonda, Autonomous University, Madrid, Spain;Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, Republic of Korea;Stem Cell Allogeneic Transplant Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA |
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| Abstract: | Background aimsSpinal cord injury is common among young subjects involved in motor vehicle accidents. Mechanisms and attempts to reverse post-traumatic pathophysiologic consequences are still being investigated. Unfortunately no effective and well-established treatment modality has been developed so far. The regeneration capability of the human nervous system following an injury is highly limitedMethodsThe study involved four patients (two male, two female) who had suffered spinal cord injury as a result of various types of trauma. On neurologic examination, all the patients were determined to be in American Spinal Injury Association (ASIA) grade A. All patients were treated with decompression, stabilization and fusion for vertebral trauma anteriorly, as well as intralesional implantation of cellular bone marrow concentrates using a posterior approach 1 month after the first operation. The patients were then treated and followed-up in the physical rehabilitation clinicResultsAt the end of the post-operative 1-year follow-up, two of the patients were classified as ASIA C while one was classified as ASIA B. One patient showed no neurologic change; none of the patients suffered from any complications or adverse effects as a result of intralesional application of bone marrow cellsConclusionsThe results of this experimental study show the potential contribution of intralesional implantation of bone marrow to neuronal regeneration in the injured spinal cord, with neuronal changes. In light of the results of this experimental study, the potential for regenerative treatment in injuries of the human spinal cord is no longer a speculation but an observation. |
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