Synthesis of amide compounds of ferulic acid,and their stimulatory effects on insulin secretion in vitro |
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Authors: | Nomura Eisaku Kashiwada Ayumi Hosoda Asao Nakamura Kozo Morishita Hideko Tsuno Takuo Taniguchi Hisaji |
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Affiliation: | Industrial Technology Center of Wakayama Prefecture, 60 Ogura, 649-6261, Wakayama, Japan. nomura@wakayama-kg.go.jp |
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Abstract: | We prepared amide compounds which were derived from ferulic acid using various amines, and investigated their stimulatory effects on insulin secretion using rat pancreatic RIN-5F cells. Most of these compounds exhibited significant promotion of the insulin-release at a concentration of 10 microM and in particular, the amides having n-butyl, n-pentyl, pyrrolidine, and piperidine groups showed high activity. |
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