Body zinc distribution profile during N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats at various levels of dietary zinc intake |
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Authors: | Woo Wendy Xu Zhaoming |
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Institution: | (1) Food, Nutrition, and Health, The University of British Columbia, V6T 1Z4 Vancouver, British Columbia, Canada |
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Abstract: | Zinc distribution is apparently altered in breast cancer patients. It is unclear if this apparent zinc redistribution is a
consequence of altered zinc nutrition or tissue-specific response to breast cancer. Our objectives were to assess effects
of N-methyl-N-nitrosourea-treatment and N-methyl-N-nitrosourea-induced mammary tumorigenesis on body zinc-distribution profile in rats and to assess effects of dietary zinc
intake on the body zinc-distribution profile during N-methyl-N-nitrosourea treatment and N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats. Female Sprague-Dawley rats were assigned to zinc-deficient (3 mg/kg diet)
or zinc-adequate (31 mg/kg diet) ad libitum or pair-fed group. Rats were sham treated or N-methyl-N-nitrosourea treated (50 mg/kg body weight; Experiment 1 or 40 mg/kg body weight; Experiment 2) (n=6). In both experiments, the zinc concentration was significantly higher (6–19 times) in mammary tumor than in mammary gland.
Tissue zinc concentration was essentially unaffected by N-methyl-N-nitrosourea treatment and tumor bearing, but was reduced by zinc deficiency in the bone, kidney, and liver. Overall, higher
mammary tumor zinc concentration and absence of zinc redistribution during N-methyl-N-nitrosourea treatment and N-methyl-N-nitrosourea-induced mammary tumorigenesis, regardless of zinc intakes, indicates zinc accumulation in mammary tumors. Because
zinc is essential for growth and cancer is characterized by uncontrolled growth, this zinc accumulation suggests an involvement
of zinc in N-methyl-N-nitrosourea-induced rat mammary tumorigenesis. |
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Keywords: | Dietary zinc intake zinc deficiency body zinc-distribution profile N-methyl-N-nitrosourea rat mammary tumorigenesis tissue zinc concentration |
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