Bleomycin stimulates both membrane (Na+-K+) ATPase and electrogenic (Na+-K+) pump and partially removes the inhibition by vanadium ions |
| |
| Authors: | F Vyskocil J Pilar H Zemková P Svoboda V Vítek J Teisinger |
| |
| Affiliation: | 1. Institute of Physiology, Czechoskovak Academy of Sciences, 142 20 Prague 4, Vídeňská 1083 Czechoslovakia |
| |
| Abstract: | Bleomycin 2 X 10(-6) and 6 X 10(-6) mol.1(-1) increased the activity of specific (Na+-K+) ATPase of the rat brain microsomes. It also stimulated the electrogenic (Na+-K+) pump in intact skeletal muscle cells. The blocking effect of vanadyl (+4V) on membrane (Na+-K+) ATPase was eliminated completely by the drug, but the action of vanadate (+5V) was counteracted only partially. Electron paramagnetic resonance spectra revealed the formation of a +4V - bleomycin complex which is still able to activate the (Na+-K+) ATPase. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
