Structure-activity relationships of some 4-quinazolylthiosemicarbazides and their triazolo derivatives |
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| Authors: | S Jantová D Hudecová K ?pirková ? Stankovský |
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| Institution: | (1) Department of Microbiology, Biochemistry and Biology, Slovak Technical University, 812 37 Bratislava, Slovakia;(2) Department of Organic Chemistry, Faculty of Chemical Technology, Slovak Technical University, 812 37 Bratislava, Slovakia |
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| Abstract: | Eigh 4-quinazolylthiosemicarbazides and nine of their structural analogues have been tested for antibacterial effects and
for structure activity relationships. 9-Chloro-5-morpholino-1,2,4-triazolo4,3-c]quinazoline-3-thione has demonstrated the hightest antibacterial effect (MIC of 1 mg/L forE. coli andP. mirabilis and <1 mg/L forS. aureus andB. subtilis). The most effective derivatives have the carbon aromatic ring substituted with chlorine and the pyrimidine ring with morpholine
or with secondary amine group. |
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