Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary |
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| Authors: | Alexei A Sharov Geppino Falco Yulan Piao Suresh Poosala Kevin G Becker Alan B Zonderman Dan L Longo David Schlessinger Minoru SH Ko |
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| Affiliation: | (1) Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 21224 Baltimore, MD, USA;(2) Research Resources Branch, National Institute on Aging, National Institutes of Health, 21224 Baltimore, MD, USA;(3) Laboratory of Immunology, National Institute on Aging, National Institutes of Health, 21224 Baltimore, MD, USA |
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| Abstract: | Background The aging of reproductive organs is not only a major social issue, but of special interest in aging research. A long-standing view of 'immortal germ line versus mortal soma' poses an important question of whether the reproductive tissues age in similar ways to the somatic tissues. As a first step to understand this phenomenon, we examine global changes in gene expression patterns by DNA microarrays in ovaries and testes of C57BL/6 mice at 1, 6, 16, and 24 months of age. In addition, we compared a group of mice on ad libitum (AL) feeding with a group on lifespan-extending 40% calorie restriction (CR). |
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