Hemostasis and ageing |
| |
| Authors: | Daniela Mari Giulia Ogliari Davide Castaldi Giovanni Vitale Elisa Mariadele Bollini Domenico Lio |
| |
| Institution: | 1.Dipartimento di Scienze Mediche e U.O. di Geriatria, IRCCS,Istituto Auxologico Italiano, Università di Milano,Milano,Italy;2.Dipartimento di Biopatologia e Metodologie Biomediche,Università di Palermo,Palermo,Italy |
| |
| Abstract: | On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related Diseases was held in Palermo, Italy. The lecture
of D. Mari on Hemostasis and ageing is summarized herein. Physiological ageing is associated with increased plasma levels
of many proteins of blood coagulation together with fibrinolysis impairment. This may be of great concern in view of the known
association between vascular and thromboembolic diseases and ageing. On the other hand, centenarians are characterized by
a state of hypercoagulability and possession of several high-risk alleles and well-known atherothrombotic risk markers but
this appears to be compatible with longevity and/or health. Parameters considered risk factors for atherosclerotic vascular
diseases in young people may lose their biological significance in advanced age and assume a different role. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
