Cell adhesion to agrin presented as a nanopatterned substrate is consistent with an interaction with the extracellular matrix and not transmembrane adhesion molecules |
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| Authors: | Tobias Wolfram Robert W Burgess |
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| Affiliation: | (1) Dept. New Materials and Biosystems, Max-Planck-Institute for Metals Research, Germany;(2) University of Heidelberg, Stuttgart, Germany;(3) Dept. of Biophysical Chemistry, University of Heidelberg, Stuttgart, Germany;(4) Institute for Molecular Biophysics, Bar Harbor, ME, USA;(5) The Jackson Laboratory, , Bar Harbor, ME, USA |
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| Abstract: | Background Molecular spacing is important for cell adhesion in a number of ways, ranging from the ordered arrangement of matrix polymers extracellularly, to steric hindrance of adhesion/signaling complexes intracellularly. This has been demonstrated using nanopatterned RGD peptides, a canonical extracellular matrix ligand for integrin interactions. Cell adhesion was greatly reduced when the RGD-coated nanoparticles were separated by more than 60 nm, indicating a sharp spacing-dependent threshold for this form of cell adhesion. |
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