| Abstract: | Prolonged repeated electric stimulation of rats striatum causes stable behavioural depression and reorganization of temporal dynamics of forced swimming. Simultaneously increases the depression index offered by us as ratio of the number of immobilization cycles shorter than 6 s to the total number of active swimming cycles. Striatectomy and amphetamine administration (1 mg/kg) uniformly change the rhythmic structure of swimming with an increase of animals general motor activity without change of the depression index. It is suggested to use striatal inactivation as a model of depression state. |
