Evaluation of reactogenicity and immunogenicity of Bubo-M, the Russian combined vaccine for immunization of adults against diphtheria, tetanus and viral hepatitis B |
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| Authors: | Fel'dblium I V Vorob'eva N N Nikolaeva A M Borisova V N Mel'nikov V A Budanov M V Iakovleva I A Kaz'ianin A V Pushkareva E V Griaznova D V Shalunova N V Perelygina O V Ozeretskovskiĭ N A Bektimirov T A Isaeva N V |
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| Affiliation: | Medical Academy, Perm, Russia. |
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| Abstract: | Bubo-M, the first Russian associated vaccine, was found to have low reactogenicity and high immunogenic potency. The frequency of postvaccinal reactions in the group of persons immunized with Bubo-M (20%) appeared to be considerably lower than among persons who received the combined injection of adsorbed DT toxoid with reduced antigen content and vaccine against hepatitis B (47.7%). Following the course of vaccination the level of anti-HBs considerably exceeded the protective level. Immune response to the diphtheria and tetanus components of Bubo-M exceeded that observed after immunization with absorbed DT toxoid with reduced antigen content (p < 0.05). |
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