Colonial differentiation in Streptomyces coelicolor depends on translation of a specific codon within the adpA gene |
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Authors: | Nguyen Kien T Tenor Jennifer Stettler Hansruedi Nguyen Lieu T Nguyen Liem D Thompson Charles J |
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Affiliation: | Department of Molecular Microbiology, Biozentrum, Universit?t Basel, 4056 Basel, Switzerland. |
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Abstract: | We identified adpA as an araC-like regulatory gene needed for colonial morphogenesis in Streptomyces coelicolor and showed that its activity depended on a unique TTA triplet corresponding to the leucyl-tRNA gene (bldA). These findings partially explained the dependence of aerial mycelium formation on a rare tRNA that is postulated to have developmental control functions. |
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