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Dynamic modeling for shear stress induced ATP release from vascular endothelial cells |
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| Authors: | Kai Rong Qin Cheng Xiang Zhe Xu Ling Ling Cao Shuzhi Sam Ge Zong Lai Jiang |
| Affiliation: | Institute of Mechanobiology and Medical Engineering, Shanghai Jiao Tong University, Mailbox 888, 800 Dongchuan Road, Minhang, Shanghai, 200240, China, krqin@sjtu.edu.cn. |
| Abstract: | A dynamic model is proposed for shear stress induced adenosine triphosphate (ATP) release from endothelial cells (ECs). The dynamic behavior of the ATP/ADP concentration at the endothelial surface by viscous shear flow is investigated through simulation studies based on the dynamic ATP release model. The numerical results demonstrate that the ATP/ADP concentration against time at endothelium-fluid interface predicted by the dynamic ATP release model is more consistent with the experimental observations than that predicted by previous static ATP release model. |
| Keywords: | Shear stress Endothelial cells ATP Mechanotransduction Dynamic model Static model Calcium dynamics |
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