Thromboxane A2 biosynthesis in human lung fibroblasts WI-38. |
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Authors: | N K Hopkins F F Sun R R Gorman |
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Affiliation: | Experimental Biology Research The Upjohn Company Kalamazoo, Michigan 49001 USA |
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Abstract: | A fibroblast of human lung origin (WI-38) synthesizes thromboxane A2 from the prostaglandin endoperoxide PGH2. Thromboxane A2 synthesis was demonstrated by radio thin layer chromatography, gas chromatography/mass spectrometry, and by bioassay. This is the first demonstration of thromboxane A2 biosynthesis in a homogeneous cell population other than the human platelet. |
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