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Thromboxane A2 biosynthesis in human lung fibroblasts WI-38.
Authors:N K Hopkins  F F Sun  R R Gorman
Affiliation:Experimental Biology Research The Upjohn Company Kalamazoo, Michigan 49001 USA
Abstract:A fibroblast of human lung origin (WI-38) synthesizes thromboxane A2 from the prostaglandin endoperoxide PGH2. Thromboxane A2 synthesis was demonstrated by radio thin layer chromatography, gas chromatography/mass spectrometry, and by bioassay. This is the first demonstration of thromboxane A2 biosynthesis in a homogeneous cell population other than the human platelet.
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