Humoral immune response to filarial antigens in chyluria |
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| Authors: | Alamelu Raja Rabia Hussain R Prabhakar P R Narayanan |
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| Institution: | (1) Tuberculosis Research Centre, 600 031 Madras, India;(2) Laboratory of Parasitic Diseases, National Institute of allergy and Infectious Diseases, National Institute of Health, 20205 Bethesda, Maryland, USA |
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| Abstract: | Humoral immune parameters like total immunoglobulins and specific antibody levels in serum were studied in filarial chyluria
patients. Mean serum IgG was significantly reduced in this group compared to normal controls, while IgA and IgM levels remained
comparable to controls. Anti-filarial antibody titre as measured by enzyme-linked immunosorbent assay also was significantly
reduced. However, the total and specific IgE antibody titre was similar to that of controls. Specific IgE contents of the
patients’ sera could be related to their microfilaraemic status. |
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| Keywords: | Chyluria humoral immunity IgE |
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