自发性高血压大鼠四氢生物碟呤治疗后动脉的结构及力学改变

目的：探讨长期四氢生物喋呤（BH4）治疗对自发性高血压大鼠（SHR）血管形态及血管力学性质的影响;方法：选用4周龄雄性SHR36只,随机分为实验组和对照组,每组18只。实验组每周2次腹腔注射BH420mg／kg,对照组注射等容量生理盐水,于实验第4、16和26周龄时各取6只测量动脉收缩压（SBP）,并使用计算机图像分析的方法分别测量主动脉血管零应力状态张开角、压力-直径关系及肠系膜动脉血管的壁／腔比值。结果：至BH4治疗后的第16和26周龄,SHR的SBP明显降低（P〈0．01）;实验组SHR胸主动脉张开角显著减小（P〈0．01）,压力-直径（P-D）关系曲线上移;实验组肠系膜动脉三级分支血管壁／腔（W／L）值减小（P〈0．05）。结论：BH4可以减弱由于长期高血压所导致的血管肥厚和管腔狭窄,恢复血管弹性。

Biomechanical properties of artery in spontaneously hypertensive rats after treating with tetrahydrobiopterin

Aim： To explore the effect of remodeling and biomechanical properties after chronic treating with tetrahydrobiopterin（BH4） in spontaneously hypertensive rats. Methods： The spontaneously hypertensive rat（SHR） were given with BH4 chronically. The opening angle in the zero-stress state , wall-to-lumen area ratios （W/L） of thoracic aorta and the relationship between pressure and diameter （P-D） of mesenterie artery were measured by computer image analysis in 4, 16, and 26 week-old respectively. Results： Treating with BH4 chronically from 4 weeks-old in SHR, there was a significant decrease in morphometric parameters of the thoracic aorta and an increase in the zero-stress state of opening angle of elastic artery. The P-D curve of mesenterie artery moved upward. Conclusion： Treating with BI44 prevented the structure and function of artery from abnormal changing, including to attenuate the resistant vascular hypertrophy and recover the vascular elasticity and expansibility.