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| Cytoplasmic Poly（A） Binding Protein 4 Is Highly Expressed in Human Colorectal Cancer and Correlates with Better Prognosis | |
| 作者姓名： | Liu D Yin B Wang Q Ju W Chen Y Qiu H Li J Peng X Lu C |
| 作者单位： | [1]Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China [2]Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, 1-tarbin 150086, China [3]National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China [4]Department of Internal Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China [5]Department of Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China [6]Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China |
| 基金项目： | the,Ph.D.Programs,Foundation,of,the,Ministry,of,Education,of,China |
| 摘 要： | Cytoplasmic poly(A) binding protein 4(PABPC4) is an RNA-processing protein that plays an important role in the regulation of gene expression.The aim of this study was to investigate the expression pattern and identify the potential clinical significance of PABPC4 in colorectal cancer.Immunohistochemical analysis revealed that 26.7%(27/101 patients) of primary colorectal tumors and 60.5%(23/38 patients) of corresponding adjacent,normal tissues showed high cytoplasmic expression of PABPC4,whereas expression was absent in 98%(43/44 patients) of distant,normal tissues.Using Kaplan-Meier analysis,we observed that the expression of PABPC4 was significantly correlated with disease-free survival and overall survival in patients with stageⅡand stageⅢcolorectal cancer(P = 0.022 and P = 0.020,respectively).PABPC4 expression was positively associated with survival outcome,and may have predictive value in the prognosis of patients with colorectal cancer.Taken together,our findings indicate that PABPC4 may play a role in the pathogenesis of colorectal cancer. |
| 关 键 词： | Colorectal cancer PABPC4 Poly(A) tail Prognosis |
Cytoplasmic poly(A) binding protein 4 is highly expressed in human colorectal cancer and correlates with better prognosis |
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| Liu D,Yin B,Wang Q,Ju W,Chen Y,Qiu H,Li J,Peng X,Lu C.Cytoplasmic poly(A) binding protein 4 is highly expressed in human colorectal cancer and correlates with better prognosis[J].Journal of Genetics and Genomics,2012,39(8):369-374. | |
| Authors: | Dan Liu Bin Yin Qiang Wang Wenyi Ju Yuanjia Chen Huizhong Qiu Ji Li Xiaozhong Peng Chongmei Lu |
| Institution: | 1. Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,Beijing 100730, China ;Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China 2. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China 3. Department of Internal Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,Beijing 100730, China 4. Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,Beijing 100730, China 5. Department of Surgery, Peking Union Medical College Hospital Peking Union Medical College. Chinese Academy of Medical Sciences, Beijing 100730, China 6. Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China |
| Abstract: | Cytoplasmic poly(A) binding protein 4 (PABPC4) is an RNA-processing protein that plays an important role in the regulation of gene expression. The aim of this study was to investigate the expression pattern and identify the potential clinical significance of PABPC4 in colorectal cancer. Immunohistochemical analysis revealed that 26.7% (27/101 patients) of primary colorectal tumors and 60.5% (23/38 patients) of corresponding adjacent, normal tissues showed high cytoplasmic expression of PABPC4, whereas expression was absent in 98% (43/44 patients) of distant, normal tissues. Using Kaplan-Meier analysis, we observed that the expression of PABPC4 was significantly correlated with disease-free survival and overall survival in patients with stage II and stage III colorectal cancer (P=0.022 and P=0.020, respectively). PABPC4 expression was positively associated with survival outcome, and may have predictive value in the prognosis of patients with colorectal cancer. Taken together, our findings indicate that PABPC4 may play a role in the pathogenesis of colorectal cancer. |
| Keywords: | Colorectal cancer PABPC4 Poly（A） tail Prognosis |
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