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Amino-caprolactam derivatives as gamma-secretase inhibitors |
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| Authors: | Parker Michael F Bronson Joanne J Barten Donna M Corsa Jason A Du Wengsheng Felsenstein Kevin M Guss Valerie L Izzarelli Darcy Loo Alice McElhone Kate E Marcin Larry R Padmanabha Ramesh Pak Roger Polson Craig T Toyn Jeremy H Varma Sam Wang Jian Wong Victoria Zheng Ming Roberts Susan B |
| Institution: | Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. parkerm@BMS.com |
| Abstract: | A series of amino-caprolactam sulfonamides were developed from a screening hit. Compounds with good in vitro and in vivo gamma-secretase activity are reported. |
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