| 单链抗体的表达 |
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| 引用本文： | 代鹏,周广青,马军武.单链抗体的表达[J].生物技术通报,2011(10). |
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| 作者姓名： | 代鹏 周广青 马军武 |
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| 作者单位： | 中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室国家口蹄疫参考实验室甘肃省生物检测工程技术研究中心,兰州,730046 |
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| 基金项目： | 中央级公益性科研院所基本科研业务费专项资金项目(B2F100306) |
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| 摘 要： | 单链抗体(scFv)是具有抗体活性的最小功能结构单位,是基因工程抗体研究领域中的热点,具有比单克隆抗体在生物病原体、微生物污染和寄生虫病等预防、检测和治疗的独特优点和应用前景.鉴于其重要性,单键抗体在不同的表达系统中得到表达与研究.简要综速了scFv的表达.
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| 关 键 词： | 单链抗体 表速系统 外源基因 |
Expression of Single-chain Variable Fragment |
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| Dai Peng,Zhou Guangqing,Ma Junwu.Expression of Single-chain Variable Fragment[J].Biotechnology Bulletin,2011(10). |
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| Authors: | Dai Peng Zhou Guangqing Ma Junwu |
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| Institution: | Dai Peng Zhou Guangqing Ma Junwu(State Key Laboratory of Veterinary Etiological Biology,National Foot and Mouth Disease Reference Laborator,Gansu Provincial Engineering and Technique Research Centre on Biological Detection,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046) |
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| Abstract: | Single chain Fragment variable(scFv) is the smallest function structure units with antibody active and the hot spots in the field of genetic engineering antibody.Compared with monoclonal antibodies,scFv features much unique advantages and application prospect in prevention,detection and treatment of biological pathogens,microbial contamination and parasitic disease.As its importance,scFv has got expressed and researched in different expression systems.scFv expression were summarized briefly. |
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| Keywords: | Single-chain variable fragment Expression system Heterologous gene |
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