| 人脑星形细胞瘤中p53，Fas/FasL 的表达及其与凋亡关系的研究 |
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| 引用本文： | 张丽红,齐蕾,单丽辉,柴翠翠,韩伟,王立峰.人脑星形细胞瘤中p53，Fas/FasL 的表达及其与凋亡关系的研究[J].现代生物医学进展,2011,11(18):3501-3503. |
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| 作者姓名： | 张丽红 齐蕾 单丽辉 柴翠翠 韩伟 王立峰 |
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| 作者单位： | 1. 哈尔滨医科大学附属第一临床医院放射科 黑龙江哈尔滨150001
2. 哈尔滨医科大学附属第一临床医院病理科 黑龙江哈尔滨150001 |
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| 基金项目： | 哈尔滨市科技创新人才专项资金项目 |
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| 摘 要： | 目的:探讨细胞凋亡在星形细胞瘤中的作用及其与p53、Fas和Fas配体(Fas ligand,FasL)的关系。方法:对43例星形细胞瘤的标本分别进行HE染色,TUNEL及免疫组化分别标记p53,Fas和FasL。结果:高级别肿瘤和低级别肿瘤间的凋亡无显著差异(P>0.05)。高级别星形细胞瘤的p53,Fas和FasL的表达均显著高于低级别肿瘤(P均<0.05)。结论:突变型p53可作为评价星形细胞瘤生物学行为的参考指标。与低级别星形细胞瘤相比,高级别肿瘤中的细胞凋亡受到了抑制,且Fas与FasL的过表达对细胞凋亡可产生明显影响。
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| 关 键 词： | 星形细胞瘤 细胞凋亡 p53 Fas/FasL |
The expression of p53, Fas /FasL and their correlation with apoptosis
in human brain astrocytomas |
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| ZHANG Li-hong,QI Lei,SHAN Li-hui,CHAI Cui-cui,HAN Wei,WANG Li-feng.The expression of p53, Fas /FasL and their correlation with apoptosis
in human brain astrocytomas[J].Progress in Modern Biomedicine,2011,11(18):3501-3503. |
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| Authors: | ZHANG Li-hong QI Lei SHAN Li-hui CHAI Cui-cui HAN Wei WANG Li-feng |
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| Institution: | ZHANG Li-hong1,QI Lei2,SHAN Li-hui2,CHAI Cui-cui2,HAN Wei2,WANG Li-feng2(1 Department of radiology,The First Hospital of the Harbin Medical University,150001,Harbin,China,2 Department of Pathology,China) |
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| Abstract: | Objective: To investigate the role of apoptosis in the progression of astrocytomas and its correlation with the expres-sion of p53 and Fas/FasL.Methods: Histopathological analysis,TUNEL labeling and immunohistochemical staining of p53 and Fas/FasL.Results: Apoptosis was not significantly different in the two groups(P>0.05);Expression of p53,Fas and FasL was significantly higher in the high-grade astrocytomas than the low-grade ones(P<0.05).Conclusion: p53 can serve as an informative parameter to evaluate th... |
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| Keywords: | Astrocytoma Apoptosis p53 Fas/FasL |
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