| 质子泵抑制剂对冠心病患者嗜铬粒蛋白A 影响的临床意义 |
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| 引用本文： | 蔡娟朱中生,叶飞陈绍良.质子泵抑制剂对冠心病患者嗜铬粒蛋白A 影响的临床意义[J].现代生物医学进展,2011,11(20):3899-3902. |
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| 作者姓名： | 蔡娟朱中生 叶飞陈绍良 |
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| 作者单位： | 南京医科大学附属南京第一医院心内科 江苏 南京210006 |
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| 摘 要： | 目的:本研究旨在探讨质子泵抑制剂(PPI)对心内科拟诊断为冠心病患者的嗜铬粒蛋白A(CgA)水平影响的临床意义。方法:113名拟诊冠心病的住院患者,分为PPI组(药物治疗中加入PPI,共62例)和非PPI组(药物治疗中无PPI,共51例),收集其外周血清,用ELISA法检测样本血清中CgA水平,同时应用化学发光法检测样本血清中NT-proBNP水平。比较PPI组和非PPI组CgA、NT-proBNP水平的差异。结果:因为CgA、NT-proBNP均为非正态分布资料,两者均通过对数转换为正态分布资料;PPI组的LN CgA的均数显著高于非PPI组(4.62±0.97和3.91±0.89,P=0.000)。而两组LN NT-proBNP的均数无显著差异(5.41±1.46和5.59±2.00,P=0.580)。结论:在心功能等临床特征具有可比性的情况下,是否使用PPI对CgA水平的影响很大;而对BNP无明显影响。评价CgA在心功能分级或冠心病预后等方面的应用,不能忽略PPI联用对CgA数值的影响。
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| 关 键 词： | 嗜铬粒蛋白A B型脑利尿钠肽前体 质子泵抑制剂 |
Effects of Proton-pump Inhibitor on Serum Chromogranin A Level in
Patients with Coronary Heart Disease |
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| CAI Juan,ZHU Zhong-sheng,YE Fei,CHEN Shao-liang.Effects of Proton-pump Inhibitor on Serum Chromogranin A Level in
Patients with Coronary Heart Disease[J].Progress in Modern Biomedicine,2011,11(20):3899-3902. |
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| Authors: | CAI Juan ZHU Zhong-sheng YE Fei CHEN Shao-liang |
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| Institution: | CAI Juan1,ZHU Zhong-sheng1,YE Fei1,CHEN Shao-liang1(Department of cardiology,Nanjing First Hospital Affiliated to Nanjing Medical University,Nanjing 210006,China) |
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| Abstract: | Objective:To study when treated with proton-pump inhibitor,where there is effect on the circulation levels of chromogranin A(CgA) in patients with the coronary heart disease.Methods:113 patients were divided into PPI group(who were treated combined with PPI) and non-PPI group(without PPI treatment),and had their circulating CgA levels measured by the commercially available ELISA assay and NT-proBNP by immunofluorcscent assays on day before coronary artery angiography.The difference in the levels of CgA,NT-p... |
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| Keywords: | Chromogranin A NT-pro BNP Proton-pump inhibitor |
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