| 基于雷帕霉素与FRB结合的蛋白质间相互作用的相关技术 |
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| 引用本文： | 李芹芹,史道华,杨牛牛. 基于雷帕霉素与FRB结合的蛋白质间相互作用的相关技术[J]. 生物技术通报, 2011, 0(9) |
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| 作者姓名： | 李芹芹 史道华 杨牛牛 |
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| 作者单位： | 1. 福建中医药大学药学院,福州,350108
2. 南京军区福州总医院药学科,福州,350025 |
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| 基金项目： | 福建省自然基金资助项目(2008J0103) |
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| 摘 要： | FKBP12-rapamycin复合物的结合位点(FKBP1 2-rapamycin binding,FRB)为雷帕霉素(rapamycin,RAP)与哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)结合的结构城,基于RAP介导FK506结合蛋白12(12 kD FK506-binging protein,FKBP12)与FRB蛋白质相互作用相关研究技术的发展与应用,使人们对小分子介导的蛋白质相互作用有了更多的认识.就研究RAP作用于FRB域及研究FKBP12-RAP-FRB三元复合物形成的相关技术作一综述,为确认新的mTOR抑制剂的作用机制及认识其他蛋白质间相互作用提供参考.
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| 关 键 词： | FRB城 雷帕霉素 蛋白质间相互作用 技术 |
Advances in Technology Based on the Combination of Rapamycin and FRB Domain Mediated Protein-protein Interactions |
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| Li Qinqin,Shi Daohua,Yang Niuniu. Advances in Technology Based on the Combination of Rapamycin and FRB Domain Mediated Protein-protein Interactions[J]. Biotechnology Bulletin, 2011, 0(9) |
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| Authors: | Li Qinqin Shi Daohua Yang Niuniu |
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| Affiliation: | Li Qinqin1 Shi Daohua2 Yang Niuniu1(1College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350108,2Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025) |
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| Abstract: | FRB domain(FKBP12-rapamycin binding domain)is a binding site of rapamycin(RAP)which targets on mTOR(mammalian target of rapamycin).As the research technologies has been used and developed based on the RAP mediated the FKBP12-FRB protein interaction,more and more mechanisms were demonstrated in protein-protein interactions induced by small molecules.In this paper,some technologies were reviewed on the study of RAP-FRB binding and FKBP12-RAP-FRB ternary complex formation which intends to recognize the mechani... |
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| Keywords: | FRB domain Rapamycin Protein-protein interactions Technology |
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