| 左旋精氨酸在冠脉搭桥术中心肌保护效果研究 |
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| 引用本文： | 池一凡,牛兆倬,陈晓伟,侯文明,孙龙,孙忠东,孙勇.左旋精氨酸在冠脉搭桥术中心肌保护效果研究[J].现代生物医学进展,2011,11(22):4285-4288. |
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| 作者姓名： | 池一凡 牛兆倬 陈晓伟 侯文明 孙龙 孙忠东 孙勇 |
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| 作者单位： | 青岛大学附属医院市立医院心脏外科 山东 青岛266000 |
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| 基金项目： | 青岛市市卫生局资助基金(2008-wszd014) |
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| 摘 要： | 目的:通过在心脏停搏液中添加适量左旋精氨酸来观察其在冠脉搭桥术中心肌保护效果。方法:选择2008年1月～2010年1月在我院行冠状动脉旁路移植术患者20例,随机分为2组,每组10例,对照组:常规心肌保护液组,不添加左旋精氨酸。实验组,心肌保护液中加入7.5g/L左旋精氨酸。测患者术前(T1)、术后6小时(T2)、术后12小时(T3)、术后24小时(T4)、术后48小时(T5)血浆中TNF-α、IL-6、IL-8及cTn I含量。记录临床观察指标。结果:两组血浆TNF-α、IL-6、IL-8、cTn I浓度术前无统计学意义(P>0.05),术后各时点TNF-α、IL-6、IL-8、cTn I浓度显著升高且实验组均低于对照组(P<0.05)。临床观察指标除血管活性药物应用情况实验组优于对照组(P<0.05)外无明显差异。结论:在心脏停搏液中加入L-精氨酸,可有效保护缺血心肌,减轻心肌再灌注损伤程度。
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| 关 键 词： | L-精氨酸 冠脉搭桥术 体外循环 心肌保护 |
Assessing Myocardial Protective Effects of L-arginine in CABG |
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| CHI Yi-fan,NFU Zhao-zhuo,CHEN Xiao-wei,HOU Wen-ming,SUN Long,SUN Zhong-dong,SUN Yong.Assessing Myocardial Protective Effects of L-arginine in CABG[J].Progress in Modern Biomedicine,2011,11(22):4285-4288. |
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| Authors: | CHI Yi-fan NFU Zhao-zhuo CHEN Xiao-wei HOU Wen-ming SUN Long SUN Zhong-dong SUN Yong |
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| Institution: | CHI Yi-fan,NIU Zhao-zhuo,CHEN Xiao-wei,HOU Wen-ming,SUN Long,SUN Zhong-dong,SUN Yong(Qingdao university affiliated hospital municipal hospital Cardiac Surgery,Shandong Qingdao,266000) |
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| Abstract: | Objective: To investigate the myocardial protective effects of L-arginine in coronary artery bypass grafting.Methods: Between January 2008 and January 2010 twenty patients with unstable angina undergoing CABG were randomized to a study and a control group,that is,L-arginine group(n=10) and control group(n=10).L-arginine was added to cardioplegia solutions in study group.A cold cardioplegic blood solution with 7.5g/L L-arginine infused for controlled reperfusion.Control patients received same protocol withou... |
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| Keywords: | L-arginine CABG Cardiopulmonary bypass Myocardial protection |
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