间充质干细胞向软骨细胞表型分化的研究进展

关节软骨自我修复能力有限,目前临床用于治疗关节软骨损伤的方法和药物均难以达到满意的效果.间充质干细胞具有分化潜力大、增殖能力强、免疫原性低、取材方便等特点,可能成为软骨组织工程的理想种子细胞之一.就间充质干细胞在软骨表型分化方面的研究进展进行了综述.系统地介绍了影响间充质干细胞向软骨细胞分化的诸多因素,如:生长因子、氧...

The Research of Mesenchymal Stem Cells Differentiate Chondrocytes

Articular cartilage has limited ability to repair and regeneration by itself. At present, the clinical treatment and drugs for articular cartilage injury are difficult to achieve satisfactory results. Mesenchymal stem cells present themselves as a promising cell source for cartilage tissue engineering, because they have great potential for multilineage differentiation, expandable in vitro without losing their differentiation type, low immunogenicity and easily obtainable in high numbers. The Mesenchymal stem cells differentiate chondrocytes was focused on and many effect factors of Mesenchymal stem cells differentiate chondrocytes, such as growth factor, oxygen concentration, scaffold and so on were systematically introduced. In addition, some opinions on MSCs as seed cells present disease and development for cartilage tissue engineering were given.