| 鼻咽癌组织ki67 表达与外周血NK 细胞的关系及意义 |
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| 引用本文： | 韦祝新,李萍,王仁生,康敏,胡凯.鼻咽癌组织ki67 表达与外周血NK 细胞的关系及意义[J].现代生物医学进展,2011,11(18):3531-3533. |
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| 作者姓名： | 韦祝新 李萍 王仁生 康敏 胡凯 |
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| 作者单位： | 1. 广西医科大学第一附属医院放疗科 广西南宁530021
2. 广西医科大学第一附属医院病理科 广西南宁530021 |
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| 基金项目： | 广西壮族自治区卫生厅医疗卫生科研课题 |
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| 摘 要： | 目的:研究鼻咽癌组织Ki67的表达及外周血NK细胞水平的意义。方法:检测66例鼻咽癌组织Ki67水平及与外周血NK细胞的百分含量。结果:Ki67表达阳性率为96.97%,与临床分期有关(r=0.290,P=0.030<0.05),与淋巴结转移状态相关性在统计学上无意义(r=0.068,P=0.412>0.05);放疗前中后鼻咽癌外周NK细胞水平差别均有统计学意义(前中、中后、前后F=0.513,0.627,0.623,P分别为0.005,0.004,0.000,均<0.05);ki67的表达与放疗后NK细胞NK值负相关(r=-0.433,P=0.017<0.05)。结论:Ki67的表达可能与临床分期有关,可能与放疗后NK值有关;Ki67表达与外周血NK细胞水平可以提示鼻咽癌组织增殖活跃程度和机体防御系统的状态。
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| 关 键 词： | 鼻咽癌 Ki67基因 NK细胞 |
Relationship between Expression of Ki-67 Protein and NK Cell
of Peripheral Blood |
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| WEI Zhu-xin,LI Ping,WANG Ren-sheng,KANG Min,HU Kai.Relationship between Expression of Ki-67 Protein and NK Cell
of Peripheral Blood[J].Progress in Modern Biomedicine,2011,11(18):3531-3533. |
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| Authors: | WEI Zhu-xin LI Ping WANG Ren-sheng KANG Min HU Kai |
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| Institution: | WEI Zhu-xin1,LI Ping2,WANG Ren-sheng1,KANG Min1,HU Kai1(Dept.of Radio Therapy of the First Affiliated Hospital of Guangxi Medical University,Nanning 530021 China) |
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| Abstract: | Objective: To investigate relationship between expression of Ki-67 protein and NK cell of peripheral blood.Methods: We detected Ki67 level of NPC tissue and NK cell percentage composition of peripheral blood in 66 NPC cases.Results: The positive rate of Ki-67 in was 96.97%,The expression intensity of Ki-67 had significant relation with the clinical stage of NPC(r=0.290,P=0.030<0.05) and no significant relation with metastasis state of lymph(r=0.068,P=0.412>0.05).There are significance differences in the lev... |
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| Keywords: | Nasopharyngeal carcinoma Ki-67 NK cell |
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