| 泛素连接酶对Notch 信号途径的调节作用 |
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| 引用本文： | 钟晨黄瑾.泛素连接酶对Notch 信号途径的调节作用[J].现代生物医学进展,2011,11(20):3981-3983. |
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| 作者姓名： | 钟晨黄瑾 |
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| 作者单位： | 新疆石河子大学医学院生化教研室新疆 石河子832002 |
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| 摘 要： | Notch信号途径是生物进化过程中高保守的信号通路,对细胞的定向发育及成熟起到决定性的作用。Notch信号途径受到多种分子机制的严格调控。近年来,多项研究均突出了泛素化在调控Notch信号途径活性中的重要性。本文就四种E3泛素连接酶Su(dx)/Itch、Sel-10、LNX以及Neuralized对于调控Notch受体及Notch信号途径配体的研究现况作一综述。
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| 关 键 词： | Notch信号途径 Su(dx)/Itch Sel-10 Neuralized LNX |
Regulated Effects of Ubiquitin Ligase on Notch Signaling Pathway |
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| ZHONG Chen,HUANG Jin.Regulated Effects of Ubiquitin Ligase on Notch Signaling Pathway[J].Progress in Modern Biomedicine,2011,11(20):3981-3983. |
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| Authors: | ZHONG Chen HUANG Jin |
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| Institution: | ZHONG Chen,HUANG Jin(Department of Biochemistry,Shihezi University,Shihezi 832002,China) |
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| Abstract: | Notch signaling pathway is a conserved signaling pathway in the organic evolution process,and plays a decisive role in the orientation of cell growth and maturation.Notch signaling pathway is regulated strictly by a varirty of molecular mechanisms.In recent years,many studies have highlighted the importance of ubiquitination in the regulate of Notch signaling pathway.This paper summarized four types of E3 ubiquitin ligase Su(dx) /Itch,Sel-10,LNX,and Neuralized regarding regulate the Notch acceptor and Notch... |
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| Keywords: | Notch signaling pathway Su(dx)/Itch Sel-10 Neuralized LNX |
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